Updates 24/7

Chewing gum has been invented that reduces the spread of Coronavirus.

A team of researchers has developed chewing that contains a plant-grown protein that acts as a “trap” for the SARS-CoV-2 virus in the hope that it will help to reduce the spread of the virus.

“Molecular Therapy Journal” published the findings of the study, which was conducted by researchers at the University of California, Los Angeles.

led by Henry Daniell at the University of Pennsylvania of Dental Medicine, and carried out in collaboration with scientists at the Perelman School of Medicine and School of Veterinary Medicine, as well as at The Wistar Institute and Fraunhofer USA, may result in a low- tool to combat the COVID-19 pandemic, according to the researchers.

We know that when a person with SARS-CoV-2 sneezes, coughs, or speaks, some of the virus can be expelled and infect others because it replicates in the salivary glands, according to Daniell, and that this can happen because the virus is transmitted through saliva.

“This gum provides us with an opportunity to neutralize the virus in the saliva, providing us with a simple way to potentially reduce a of transmission,” he continued, before adding that the gum is also beneficial for other reasons.

COVID-19 vaccinations have contributed to a change in the course of the pandemic, but they have not completely stopped the spread of the disease. The virus can infect even people who have received a complete vaccination against SARS-CoV-2 and, according to recent research, can have a viral load comparable to that of unvaccinated individuals.

ACE2 is a protein that Daniell had been studying in the context of treating high pressure prior to the pandemic that claimed his life. They were able to grow this protein as well as a number of other proteins with therapeutic potential because his laboratory had developed a patented plant-based production system. When they bombarded plant material with target protein DNA, it was possible for the researchers to coax chloroplasts in plants to accept and begin producing proteins as a result of their efforts. For example, protein could be delivered to the body through the consumption of freeze-dried and ground-up plant material. This system has the potential to overcome many of the traditional obstacles associated with protein drug synthesis, such as the need for an expensive production and purification process.

Because of the COVID-19 pandemic, Daniell’s previous research on ACE2 was conducted at a particularly advantageous time. This is a fortunate coincidence, as the ACE2 receptor on human cells also binds the SARS-CoV-2 spike protein, which is another fortunate coincidence. It had previously been demonstrated by a number of other research groups that injections of ACE2 could reduce viral load in patients suffering from infections.

Dan Daniell and Hyun (Michel) Koo, a colleague at Penn Dental Medicine, were working on developing chewing gum that would contain plant-grown proteins that would inhibit the growth of dental plaque in the mouth. Daniell wondered if a gum infused with ACE2 proteins derived from plants could be used to neutralize SARS-CoV-2 in the oral cavity, given his newfound of ACE2 and the advancement of technology.

For answers, he turned to Dr. Ronald Collman at the University of Pennsylvania School of Medicine. Dr. Collman’s team had been collecting blood, nasal swabs, saliva, and other biospecimens from COVID patients since the beginning of the pandemic for scientific research purposes since the beginning of the pandemic.

Henry’s approach required samples, so I contacted him to inquire whether we had any, what kind of samples would be appropriate for testing, and whether we could internally validate the level of SARS-CoV-2 virus in the saliva samples, Collman explained.

This resulted in a cross-school collaboration that was built on the findings of our microbiome research, he went on to .

Plants were grown to produce ACE2, which was then combined with another compound that allowed the protein to cross mucosal barriers and aid in the binding process. The resulting plant material was then used to make cinnamon-flavored gum tablets, which were then tested for their ability to reduce tooth decay. According to the findings, ACE2 was found to be effective in neutralizing SARS-CoV-2 viruses when samples obtained from nasopharyngeal swabs from COVID-positive patients were incubated with the gum for an period of time.

The Wistar Institute and Penn Vet conducted additional research in which viruses that were less pathogenic than SARS-CoV-2 were engineered to express the SARS-CoV-2 spike protein, resulting in the discovery of a new virus strain. The researchers discovered that the gum was effective at preventing the entry of viruses or viral particles into cells, either by binding directly to the spike protein on the surface of the cells or by inhibiting the ACE2 receptor on the surface of the cells, as previously reported.

The researchers eventually exposed saliva samples from COVID-19 patients to the ACE2 gum and discovered that viral RNA levels dropped so dramatically that they were virtually undetectable.

Now, the research team is working to gain approval for a clinical trial to determine whether the approach is safe and effective when tested on people who have been infected with SARS-CoV-2.

In Collman’s words, “Henry’s approach of producing proteins in plants and consuming them orally is inexpensive, and it has the potential to be scaled up.”

According to the researchers, while the research is still in its early stages, if clinical trials demonstrate that the gum is safe and effective, it could be administered to patients whose infection is unknown or even during dental check-ups, when masks must be removed in order to reduce the likelihood of the virus being passed onto caregivers, according to them.

According to Daniell, “We are already utilizing masks and other physical barriers to reduce the likelihood of transmission.” ”

“This gum could be used as an additional tool in that fight,” he said in his conclusion.

Leave A Reply

Your email address will not be published.

Comment moderation is enabled. Your comment may take some time to appear.